Telbivudine exhibits no inhibitory activity against HIV-1 clinical isolates in vitro.

نویسندگان

  • Kai Lin
  • Sylwia Karwowska
  • Eric Lam
  • Kay Limoli
  • Thomas G Evans
  • Claudio Avila
چکیده

Most approved drugs with activity against hepatitis B virus (HBV) have activity against human immunodeficiency virus type 1 (HIV-1), which precludes their use in patients who are coinfected with HBV and HIV-1 and who are not receiving antiretroviral therapy due to the risk of inducing resistance. The activity of telbivudine, a highly selective HBV inhibitor, against temporally and geographically distinct wild-type and multidrug-resistant HIV-1 clinical isolates was evaluated in vitro. No inhibition was observed with up to 600 muM drug, which supports further exploration of telbivudine as a therapeutic option for the treatment of HBV infections in patients coinfected with HIV-1.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 54 6  شماره 

صفحات  -

تاریخ انتشار 2010